Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Tumour budding is an emerging prognostic biomarker in colorectal cancer (CRC) and other
solid cancers. Tumour buds are usually defined as isolated single cancer cells or clusters of …

Although it has long been known that the immune cell composition has a strong prognostic
and predictive value in colorectal cancer (CRC), scoring systems such as the immunoscore …

The widespread adoption of whole slide imaging has increased the demand for effective
and efficient gigapixel image analysis. Deep learning is at the forefront of computer vision …

Tumor immune microenvironment (TIME) consists of intra-tumor immunological components
and plays a significant role in tumor initiation, progression, metastasis, and response to …

Background Conventional immunohistochemistry technologies were limited by the inability
to simultaneously detect multiple markers and the lack of identifying spatial relationships …

Comparing the performance of different continuous glucose monitoring (CGM) systems is
challenging due to the lack of comprehensive guidelines for clinical study design. In …

Rationale: Subsets of patients with early-stage lung adenocarcinoma (LUAD) have a poor
post-surgical course after curative surgery. However, biomarkers stratifying this high-risk …

In this chapter, we present the concept that digital pathology and artificial intelligence can
add value and speed to a pathologist's diagnosis while striving toward precision medicine …

The Immunoscore is a method to quantify the immune cell infiltration within cancers to
predict the disease prognosis. Previous immune profiling approaches relied on limited …