Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Parkinson's disease (PD) is a common and progressive neurodegenerative disease, caused
by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain …

Objective We hypothesized that specific mutations in the β‐glucocerebrosidase gene (GBA)
causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive …

The ability to use blood to predict the outcomes of Parkinson's disease, including disease
progression and cognitive and motor complications, would be of significant clinical value …

Background Several reports have identified different patterns of Parkinson's disease
progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall …

Background Cognitive decline is a debilitating manifestation of disease progression in
Parkinson's disease. We aimed to develop a clinical–genetic score to predict global …

Abstract Changes in the blood-based RNA transcriptome have the potential to inform
biomarkers of Parkinson's disease (PD) progression. Here we sequenced a discovery set of …

A key driver of patients' well-being and clinical trials for Parkinson's disease (PD) is the
course that the disease takes over time (progression and prognosis). To assess how genetic …

Abstract Characterization of Parkinson's disease (PD) progression using real-world
evidence could guide clinical trial design and identify subpopulations. Efforts to curate …