Toll-like receptor signalling in B cells during systemic lupus erythematosus
B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …
Altered B cell signalling in autoimmunity
DJ Rawlings, G Metzler, M Wray-Dutra… - Nature reviews …, 2017 - nature.com
Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
Dysregulated naive B cells and de novo autoreactivity in severe COVID-19
Severe SARS-CoV-2 infection has been associated with highly inflammatory immune
activation since the earliest days of the COVID-19 pandemic,,–. More recently, these …
activation since the earliest days of the COVID-19 pandemic,,–. More recently, these …
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
CM Tipton, CF Fucile, J Darce, A Chida, T Ichikawa… - Nature …, 2015 - nature.com
Acute systemic lupus erythematosus (SLE) courses with surges of antibody-secreting cells
(ASCs) whose origin, diversity and contribution to serum autoantibodies remain unknown …
(ASCs) whose origin, diversity and contribution to serum autoantibodies remain unknown …
Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity
V Sisirak, B Sally, V d'Agati, W Martinez-Ortiz… - Cell, 2016 - cell.com
Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus
(SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease …
(SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease …
Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells
Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth
impairments. Individuals with DS are also prone to severe infections and autoimmunity …
impairments. Individuals with DS are also prone to severe infections and autoimmunity …
Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity
Chronic infectious diseases have a substantial impact on the human B cell compartment
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …
including a notable expansion of B cells here termed atypical B cells (ABCs). Using …
Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus
Disclosures: P. Izmirly reported personal fees from GlaxoSmithKline outside the submitted
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …
work. JP Buyon reported personal fees from Bristol-Myers Squibb LN advisory board …
Anti-double stranded DNA antibodies: origin, pathogenicity, and targeted therapies
X Wang, Y **a - Frontiers in immunology, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …