How can machine learning and multiscale modeling benefit ocular drug development?
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …
drug delivery space, distinctive barriers, and complicated biomechanical processes …
Quantitative imaging biomarkers in age-related macular degeneration and diabetic eye disease: a step closer to precision medicine
The management of retinal diseases relies heavily on digital imaging data, including optical
coherence tomography (OCT) and fluorescein angiography (FA). Targeted feature extraction …
coherence tomography (OCT) and fluorescein angiography (FA). Targeted feature extraction …
[HTML][HTML] Radiomics-based assessment of OCT angiography images for diabetic retinopathy diagnosis
L Carrera-Escalé, A Benali, AC Rathert… - Ophthalmology …, 2023 - Elsevier
Purpose To evaluate the diagnostic accuracy of machine learning (ML) techniques applied
to radiomic features extracted from OCT and OCT angiography (OCTA) images for diabetes …
to radiomic features extracted from OCT and OCT angiography (OCTA) images for diabetes …
Perspectives on diabetic retinopathy from advanced retinal vascular imaging
JX Ong, AA Fawzi - Eye, 2022 - nature.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes and the most common
cause of acquired vision loss in adults worldwide. DR is associated with long-term chronic …
cause of acquired vision loss in adults worldwide. DR is associated with long-term chronic …
Radiomics in ophthalmology: a systematic review
H Zhang, H Zhang, M Jiang, J Li, J Li, H Zhou… - European …, 2024 - Springer
Background Radiomics holds great potential in medical image analysis for various
ophthalmic diseases. In recent times, there have been numerous endeavors in this area of …
ophthalmic diseases. In recent times, there have been numerous endeavors in this area of …
Retinal microvasculature: a potential window into heart failure prevention
Endothelial dysfunction and microvascular disease have been shown to play an important
role in the development and progression of heart failure (HF). Retinal imaging provides a …
role in the development and progression of heart failure (HF). Retinal imaging provides a …
Multi-compartment spatially-derived radiomics from optical coherence tomography predict anti-VEGF treatment durability in macular edema secondary to retinal …
SS Kar, DD Sevgi, V Dong… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
Objective: Diabetic macular edema (DME) and retinal vein occlusion (RVO) are the leading
causes of visual impairments across the world. Vascular endothelial growth factor (VEGF) …
causes of visual impairments across the world. Vascular endothelial growth factor (VEGF) …
Combination of optical coherence tomography-derived shape and texture features are associated with development of sub-foveal geographic atrophy in dry AMD
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration
(AMD) that leads to progressive and irreversible vision loss. Identifying patients with greatest …
(AMD) that leads to progressive and irreversible vision loss. Identifying patients with greatest …
[HTML][HTML] OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration
Purpose No established biomarkers currently exist for therapeutic efficacy and durability of
anti–VEGF therapy in neovascular age-related macular degeneration (nAMD). This study …
anti–VEGF therapy in neovascular age-related macular degeneration (nAMD). This study …
[HTML][HTML] Radiomics-based prediction of anti-VEGF treatment response in neovascular age-related macular degeneration with pigment epithelial detachment
RC Williamson, A Selvam, V Sant… - … Vision Science & …, 2023 - jov.arvojournals.org
Purpose: Machine learning models based on radiomic feature extraction from clinical
imaging data provide effective and interpretable means for clinical decision making. This …
imaging data provide effective and interpretable means for clinical decision making. This …