How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

Quantitative imaging biomarkers in age-related macular degeneration and diabetic eye disease: a step closer to precision medicine

G Kalra, SS Kar, DD Sevgi, A Madabhushi… - Journal of Personalized …, 2021 - mdpi.com
The management of retinal diseases relies heavily on digital imaging data, including optical
coherence tomography (OCT) and fluorescein angiography (FA). Targeted feature extraction …

[HTML][HTML] Radiomics-based assessment of OCT angiography images for diabetic retinopathy diagnosis

L Carrera-Escalé, A Benali, AC Rathert… - Ophthalmology …, 2023 - Elsevier
Purpose To evaluate the diagnostic accuracy of machine learning (ML) techniques applied
to radiomic features extracted from OCT and OCT angiography (OCTA) images for diabetes …

Perspectives on diabetic retinopathy from advanced retinal vascular imaging

JX Ong, AA Fawzi - Eye, 2022 - nature.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes and the most common
cause of acquired vision loss in adults worldwide. DR is associated with long-term chronic …

Radiomics in ophthalmology: a systematic review

H Zhang, H Zhang, M Jiang, J Li, J Li, H Zhou… - European …, 2024 - Springer
Background Radiomics holds great potential in medical image analysis for various
ophthalmic diseases. In recent times, there have been numerous endeavors in this area of …

Retinal microvasculature: a potential window into heart failure prevention

T Chaikijurajai, JP Ehlers, WHW Tang - Heart Failure, 2022 - jacc.org
Endothelial dysfunction and microvascular disease have been shown to play an important
role in the development and progression of heart failure (HF). Retinal imaging provides a …

Multi-compartment spatially-derived radiomics from optical coherence tomography predict anti-VEGF treatment durability in macular edema secondary to retinal …

SS Kar, DD Sevgi, V Dong… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
Objective: Diabetic macular edema (DME) and retinal vein occlusion (RVO) are the leading
causes of visual impairments across the world. Vascular endothelial growth factor (VEGF) …

Combination of optical coherence tomography-derived shape and texture features are associated with development of sub-foveal geographic atrophy in dry AMD

SS Kar, H Cetin, J Abraham, SK Srivastava… - Scientific Reports, 2024 - nature.com
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration
(AMD) that leads to progressive and irreversible vision loss. Identifying patients with greatest …

[HTML][HTML] OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration

SS Kar, H Cetin, L Lunasco, TK Le, R Zahid… - Ophthalmology …, 2022 - Elsevier
Purpose No established biomarkers currently exist for therapeutic efficacy and durability of
anti–VEGF therapy in neovascular age-related macular degeneration (nAMD). This study …

[HTML][HTML] Radiomics-based prediction of anti-VEGF treatment response in neovascular age-related macular degeneration with pigment epithelial detachment

RC Williamson, A Selvam, V Sant… - … Vision Science & …, 2023 - jov.arvojournals.org
Purpose: Machine learning models based on radiomic feature extraction from clinical
imaging data provide effective and interpretable means for clinical decision making. This …