Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

The nucleus is the largest organelle and is commonly depicted in the center of the cell. Yet
during cell division, migration, and differentiation, it frequently moves to an asymmetric …

During metazoan development, immune surveillance and cancer dissemination, cells
migrate in complex three-dimensional microenvironments,–. These spaces are crowded by …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …

Directed cell migration is critical for embryogenesis and organ development, wound healing
and the immune response. Microtubules are dynamic polymers that control directional …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

Microtubules control cell architecture by serving as a scaffold for intracellular transport,
signaling, and organelle positioning. Microtubules are intrinsically polarized, and their …

Neutrophil nuclear morphology has historically been used in haematology for neutrophil
identification and characterisation, but its exact role in neutrophil function has remained …

VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of
endothelial cell junctions and by inducing cell migration. Here, we show that VEGF-induced …