Background Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL-ACT) has
consistently shown efficacy in advanced melanoma. New results in the field provide now the …

Ovarian cancer (OC) represents ecosystems of highly diverse tumor microenvironments
(TMEs). The presence of tumor-infiltrating lymphocytes (TILs) is linked to enhanced immune …

Adoptive cell therapy (ACT) using in vitro expanded tumor-infiltrating lymphocytes (TILs) has
inconsistent clinical responses. To better understand determinants of therapeutic success …

Expansion of antigen-experienced CD8+ T cells is critical for the success of tumour-
infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer. Interleukin-2 …

The tumour microenvironment is programmed by cancer cells and substantially influences
anti-tumour immune responses,. Within the tumour microenvironment, CD8+ T cells undergo …

Solid tumours exhibit a well‐defined architecture, comprising a differentiated core and a
dynamic border that interfaces with the surrounding tissue. This border, characterised by …

Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, but
recent studies suggest that IFNγ-resistant tumours can be sensitised for immunotherapy, yet …

A central challenge in develo** personalized cancer cell immunotherapy is the
identification of tumor-reactive T cell receptors (TCRs). By exploiting the distinct …

Schoenfeld and colleagues report, in this issue, a measurable objective response rate in
6/28 (21.4%) of patients with advanced non–small cell lung cancer treated with lifileucel, a …

The role of myeloid cells in tumor immunity is multifaceted. While dendritic cells support T
cell-mediated tumor control, the highly heterogenous populations of macrophages …