From antimicrobial to anticancer peptides. A review

D Gaspar, AS Veiga, MARB Castanho - Frontiers in microbiology, 2013 - frontiersin.org
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms. Although AMPs have been essentially studied and developed as potential …

[HTML][HTML] Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications

B Deslouches, YP Di - Oncotarget, 2017 - ncbi.nlm.nih.gov
In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …

[HTML][HTML] Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs

S Riedl, D Zweytick, K Lohner - Chemistry and physics of lipids, 2011 - Elsevier
Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …

The interaction of antimicrobial peptides with membranes

OG Travkova, H Moehwald, G Brezesinski - Advances in colloid and …, 2017 - Elsevier
The interaction of antimicrobial peptides (AMPs) with biological membranes is in the focus of
research since several years, and the most important features and modes of action of AMPs …

Antimicrobial Peptides with Anti-Candida Activity

A Perez-Rodriguez, E Eraso, G Quindós… - International journal of …, 2022 - mdpi.com
Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is
the most usual, presenting a high morbidity and mortality. Candida albicans remains the …

Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects

AA Baxter, FT Lay, IKH Poon, M Kvansakul… - Cellular and Molecular …, 2017 - Springer
There is an ongoing need for effective and targeted cancer treatments that can overcome the
detrimental side effects presented by current treatment options. One class of novel …

On the selectivity and efficacy of defense peptides with respect to cancer cells

F Harris, SR Dennison, J Singh… - Medicinal research …, 2013 - Wiley Online Library
Here, we review potential determinants of the anticancer efficacy of innate immune peptides
(ACPs) for cancer cells. These determinants include membrane‐based factors, such as …

[HTML][HTML] Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistance

AH Benfield, F Vernen, RSE Young, F Nadal-Bufí… - Pharmacological …, 2024 - Elsevier
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and
this is particularly true for patients with metastatic melanoma that carry a BRAF V600E …

Anticancer β-hairpin peptides: membrane-induced folding triggers activity

C Sinthuvanich, AS Veiga, K Gupta… - Journal of the …, 2012 - ACS Publications
Several cationic antimicrobial peptides (AMPs) have recently been shown to display
anticancer activity via a mechanism that usually entails the disruption of cancer cell …

[HTML][HTML] Arthropod venoms and cancer

TE Heinen, ABG da Veiga - Toxicon, 2011 - Elsevier
Many active principles produced by animals, plants and microorganisms have been
employed in the development of new drugs to treat diseases such as cancer. Among the …