[HTML][HTML] Exposure to polycyclic aromatic hydrocarbons with special focus on cancer

T Rengarajan, P Rajendran, N Nandakumar… - Asian pacific journal of …, 2015 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds consisting of two or
more fused aromatic rings. Most of them are formed during incomplete combustion of …

The mitochondrial translocator protein (TSPO, 18ákDa): A key multifunctional molecule in liver diseases

Y Li, L Chen, V Papadopoulos - Biochimie, 2024 - Elsevier
Translocator protein (TSPO, 18ákDa), previously known as peripheral-type benzodiazepine
receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located …

Optimisation of the extraction of crude polysaccharides from Clinacanthus nutans leaves for antioxidant applications: Content analysis, chemometrics and …

K Devasvaran, B Alallam, V Lim - Industrial Crops and Products, 2023 - Elsevier
This study aimed to evaluate the optimal method for extracting crude polysaccharides from
Clinacanthus nutans leaves (CNP) as natural antioxidants. Five different extraction methods …

[HTML][HTML] Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events

T Gopalakrishnan, S Ganapathy, V Veeran… - Biomedicine & …, 2019 - Elsevier
The structural integrity and excellent immune system of the skin makes it a protective
covering, inspite of its exposure to hazardous compounds. In the present study, the …

Altered histone abundance as a mode of ovotoxicity during 7, 12-dimethylbenz [a] anthracene exposure with additive influence of obesity

JK Rishi, K Timme, HE White, KC Kerns… - Biology of …, 2024 - academic.oup.com
Histones are slowly evolving chromatin components and chromatin remodeling can
incorporate histone variants differing from canonical histones as an epigenetic modification …

Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of retinitis pigmentosa

EY Popova, YI Kawasawa, SSM Zhang… - Journal of …, 2021 - jneurosci.org
Epigenetic modifiers are increasingly being investigated as potential therapeutics to modify
and overcome disease phenotypes. Diseases of the nervous system present a particular …

Butyrate inhibits the mitochondrial complex Ι to mediate mitochondria-dependent apoptosis of cervical cancer cells

K Zhang, X Ji, Z Song, W Song, Q Huang, T Yu… - … medicine and therapies, 2023 - Springer
Background Cervical cancer (CC) is a common gynecological malignancy with high
morbidity worldwide. Butyrate, a short-chain fatty acid produced by intestinal flora, has been …

Obesity partially potentiates dimethylbenz [a] anthracene-exposed ovotoxicity by altering the DNA damage repair response in mice

JK Rishi, K Timme, HE White, KC Kerns… - Biology of …, 2023 - academic.oup.com
Obesity adversely affects reproduction, impairing oocyte quality, fecundity, conception, and
implantation. The ovotoxicant, dimethylbenz [a] anthracene, is biotransformed into a …

Histone deacetylase 1 is essential for rod photoreceptor differentiation by regulating acetylation at histone H3 lysine 9 and histone H4 lysine 12 in the mouse retina

RC Ferreira, EY Popova, J James, MRS Briones… - Journal of Biological …, 2017 - jbc.org
Histone acetylation has a regulatory role in gene expression and is necessary for proper
tissue development. To investigate the specific roles of histone deacetylases (HDACs) in rod …

Differential microRNAs Expression during Cancer Development, and Chemoprevention by Natural Compounds: A Comprehensive Review

C Pandey, P Tiwari - Journal of Environmental Pathology …, 2024 - dl.begellhouse.com
MicroRNAs are short non-coding RNAs that inhibit gene expression at the post-
transcriptional level. Abnormal microRNA expression has been associated with different …