Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Regulation of exercise blood flow: role of free radicals

JD Trinity, RM Broxterman, RS Richardson - Free Radical Biology and …, 2016 - Elsevier
During exercise, oxygen and nutrient rich blood must be delivered to the active skeletal
muscle, heart, skin, and brain through the complex and highly regulated integration of …

Evolocumab, a PCSK9‐monoclonal antibody, rapidly reverses coronary artery endothelial dysfunction in people living with HIV and people with dyslipidemia

TM Leucker, G Gerstenblith, M Schär… - Journal of the …, 2020 - Am Heart Assoc
Background PCSK9 (proprotein convertase subtilisin/kexin type 9) is well recognized for its
important role in cholesterol metabolism. Elevated levels are associated with increased …

Coronary endothelial dysfunction is associated with elevated serum PCSK9 Levels in people with HIV independent of low‐density lipoprotein cholesterol

TM Leucker, RG Weiss, M Schär… - Journal of the …, 2018 - Am Heart Assoc
Background HIV+ people are at increased risk of coronary artery disease, but the
responsible mechanisms are incompletely understood. Proprotein convertase …

Imaging assessment of endothelial function: an index of cardiovascular health

AS Minhas, E Goerlich, MC Corretti… - Frontiers in …, 2022 - frontiersin.org
Endothelial dysfunction is a key early mechanism in a variety of cardiovascular diseases
and can be observed in larger conduit arteries as well as smaller resistance vessels …

Lipoprotein (a) is elevated and inversely related to coronary endothelial function in people with HIV

DS Kikuchi, YA Kwapong, M Schär… - Journal of the …, 2024 - ahajournals.org
Background HIV‐associated cardiovascular disease (CVD) is increasing in prevalence. The
mechanisms underlying the heightened cardiovascular risk faced by people with HIV (PWH) …

[HTML][HTML] Exercise cardiovascular magnetic resonance: development, current utility and future applications

TP Craven, CW Tsao, A La Gerche… - Journal of …, 2020 - Elsevier
Stress cardiac imaging is the current first line investigation for coronary artery disease
diagnosis and decision making and an adjunctive tool in a range of non-ischaemic …

A clinical approach to multimodality imaging in pulmonary hypertension

C Farrell, A Balasubramanian, AG Hays… - Frontiers in …, 2022 - frontiersin.org
Pulmonary hypertension (PH) is a clinical condition characterized by progressive elevations
in mean pulmonary artery pressures and right ventricular dysfunction, associated with …

Coronary artery endothelial dysfunction is present in HIV-positive individuals without significant coronary artery disease

M Iantorno, M Schär, S Soleimanifard, TT Brown… - Aids, 2017 - journals.lww.com
Objective: HIV-positive (HIV+) individuals experience an increased burden of coronary
artery disease (CAD) not adequately accounted for by traditional CAD risk factors. Coronary …

Coronary microvascular dysfunction in HIV: a review

L Rethy, MJ Feinstein, A Sinha… - Journal of the …, 2020 - Am Heart Assoc
In the United States,> 1 million people are living with HIV, and% 50% are> 50 years old. 1
Potent combination antiretroviral therapy (ART) has significantly reduced the morbidity and …