Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Objective To conduct a systematic review and meta‐analysis of studies that measured
cytokine and chemokine levels in individuals with major depressive disorder (MDD) …

Major depressive disorder is a serious mental disorder that profoundly affects an individual's
quality of life. Although the aetiologies underlying this disorder remain unclear, an …

Stressors are imminent or perceived challenges to homeostasis. The stress response is an
innate, stereotypic, adaptive response to stressors that has evolved in the service of …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Summary Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic
processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 …

Astrocyte dysfunction and inflammation are associated with the pathogenesis of major
depressive disorder (MDD). However, the mechanisms underlying these effects remain …