Holistic approach to immune checkpoint inhibitor-related adverse events

R Poto, T Troiani, G Criscuolo, G Marone… - Frontiers in …, 2022‏ - frontiersin.org
Immune checkpoint inhibitors (ICIs) block inhibitory molecules, such as cytotoxic T-
lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), or its …

[HTML][HTML] The role of gut microbiota and leaky gut in the pathogenesis of food allergy

R Poto, W Fusco, E Rinninella, M Cintoni, F Kaitsas… - Nutrients, 2023‏ - mdpi.com
Food allergy (FA) is a growing public health concern, with an increasing prevalence in
Western countries. Increasing evidence suggests that the balance of human gut microbiota …

Basophils beyond allergic and parasitic diseases

R Poto, S Loffredo, G Marone, A Di Salvatore… - Frontiers in …, 2023‏ - frontiersin.org
Basophils bind IgE via FcεRI-αβγ2, which they uniquely share only with mast cells. In doing
so, they can rapidly release mediators that are hallmark of allergic disease. This …

Targeting the gut microbiota in inflammatory bowel diseases: where are we?

N Benech, H Sokol - Current Opinion in Microbiology, 2023‏ - Elsevier
Highlights•IBD is characterized by a vicious circle between altered host and microbiota
factors.•The gut microbiota is identified as a new therapeutic and diagnostic …

Potential interaction between the oral microbiota and COVID-19: a meta-analysis and bioinformatics prediction

L Tan, MM Zhong, Q Liu, Y Chen, YQ Zhao… - Frontiers in Cellular …, 2023‏ - frontiersin.org
Objectives The purpose of this study was to evaluate available evidence on the association
between the human oral microbiota and coronavirus disease 2019 (COVID-19) and …

Disturbed lipid profile in common variable immunodeficiency–a pathogenic loop of inflammation and metabolic disturbances

SF Jorgensen, ME Macpherson… - Frontiers in …, 2023‏ - frontiersin.org
The relationship between metabolic and inflammatory pathways play a pathogenic role in
various cardiometabolic disorders and is potentially also involved in the pathogenesis of …

Unraveling the interplay of dopamine, carbon monoxide, and heme oxygenase in neuromodulation and cognition

N Bauer, D Liu, TP Nguyen, B Wang - ACS Chemical …, 2024‏ - ACS Publications
The dopaminergic system plays important roles in neuromodulation, including prominent
roles in complex neurological functions such as cognition, reward, motivation, and memory …

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

R Poto, A Pecoraro, AL Ferrara, A Punziano… - Frontiers in …, 2023‏ - frontiersin.org
Introduction Common variable immunodeficiency (CVID) is the most prevalent symptomatic
primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial …

Breast cancer detection model using fuzzy entropy segmentation and ensemble classification

S Vidivelli, SS Devi - Biomedical Signal Processing and Control, 2023‏ - Elsevier
According to studies, breast cancer is the deadliest disease and the main cause of the
elevated mortality rates among women. The main method for detecting breast cancer is …

Fecal microbiota transplantation in a patient with chronic diarrhea and primary and secondary immunodeficiency (common variable immunodeficiency and …

K Napiórkowska-Baran, J Biliński, M Pujanek… - Frontiers in Cellular …, 2024‏ - frontiersin.org
The gut microbiota serves a crucial role in the development of host immunity.
Immunocompromised patients are particularly vulnerable to dysbiosis not only by virtue of a …