Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlap** processes, as successfully metastasizing cells assume …

Cancer biology involves complex, dynamic interactions between cancer cells and their
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology,
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …

In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …

The extracellular matrix (ECM) is a highly complex structure through which biochemical and
mechanical signals are transmitted. In processes of cell migration, the ECM also acts as a …

Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

The collection of microbes that live in and on the human body–the human microbiome–can
impact on cancer initiation, progression, and response to therapy, including cancer …

Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer
therapy today. However, evolving resistance to one drug may come at a cost of decreased …