In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Methylation is an essential biochemical mechanism that is central to the transmission of life,
and crucially responsible for regulating gametogenesis and continued embryo development …

Purpose To evaluate the possibility of correcting metabolic defects in gametes and embryos
due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by …

Purpose MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-
nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in …

Purpose Recurrent pregnancy loss (RPL) is affecting 1–4% of women who conceive
approximately, and no cause could be found in more than 50% of women suffering from …

Methylation is a crucially important ubiquitous biochemical process, which covalently adds
methyl groups to a variety of molecular targets. It is the key regulatory process that …

The role of male factors in recurrent pregnancy loss (RPL) is receiving increased attention
since sperm quantity and quality, male genetic mutations, as well as epigenetic …

Assisted reproductive technology is today considered a safe and reliable medical
intervention, with healthy live births a reality for many IVF and ICSI treatment cycles …

Background: Approximately 10%(190 million) of women worldwide are affected by
endometriosis, ectopic deposits of endometrial tissue that create a major source of pain that …

Almost 1600 individuals from the Polish population were recruited to this study. Among them
319 were fertile couples, 289 were recurrent spontaneous abortion (RSA) couples, and 131 …