Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from
metastatic disease. Combating cancer metastasis and post-therapeutic recurrence …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

Understanding cellular metabolism holds immense potential for develo** new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Ancient Egyptians believed cancer to be a curse, as seen from evidence as old as 3000 BC
from the Edwin Smith Papyrus which described breast cancer and Ebers Papyrus dated …

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Dysbiosis of the human oral microbiota has been reported to be associated with oral cavity
squamous cell carcinoma (OSCC) while the host-microbiota interactions with respect to the …