In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

Amino acids are natural compounds that can be safely used in pharmaceutical applications.
Considering the great interest in the amino acids used in the pharmaceutical industry, this …

Abstract A new sensor H 5 L for continuous identification of Cu 2+, Al 3+ and lysine was
synthesized by Schiff base reactions. The sensor could specifically recognized Cu 2+ in the …

Co-crystals are one of the most popular ways to modify the physicochemical properties of
active pharmaceutical ingredients (API) without changing pharmacological activity through …

Abstract α, α-Disubstituted α-amino acids (α-AAs) have improved properties compared to
other types of amino acids. They serve as modifiers of peptide conformation and as …

Myricetin shows low oral bioavailability (< 10%) in rats due to poor aqueous solubility,
although it has demonstrated various pharmacological activities such as those related to …