Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

The polydimethylsiloxane (PDMS) is popular for wide application in various fields of
microfluidics, microneedles, biology, medicine, chemistry, optics, electronics, architecture …

Nanobubbles (NBs) have recently garnered widespread attention for their potential use as
dual diagnostic and therapeutic agents. Similar to their micron-sized relatives …

Colorectal cancer (CRC) is a heterogeneous and molecularly complex disease, associated
with high mortality worldwide, exposing the urgent need for novel therapeutic approaches …

Most cancer patients receive chemotherapy at some stage of their treatment which makes
improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large …

Lipid-shelled nanobubbles (NBs) are emerging as potential dual diagnostic and therapeutic
agents. Similar to their micron-scale counterparts, microbubbles (1–10 μm), they can act as …

Many different strategies can be found in the literature to model organ physiology, tissue
functionality, and disease in vitro; however, most of these models lack the physiological fluid …

Abstract Two-dimensional (2D) cultures do not fully reflect the human organs' physiology
and the real effectiveness of the used therapy. Therefore, three-dimensional (3D) models …

Basic pre-clinical research based on 2D cultures have been very valuable in colorectal
cancer (CRC) research but still have failed to improve patient prognostic outcomes. This is …

Lipid shell-stabilized nanoparticles with a perfluorocarbon gas-core, or nanobubbles, have
recently attracted attention as a new contrast agent for molecular ultrasound imaging and …