Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Cancer-associated fibroblasts (CAF) are major players in the progression and drug
resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell …

Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …

In yeast, the transmembrane protein kinase/endoribonuclease Ire1p activated by
endoplasmic reticulum stress cleaves HAC1 mRNA, leading to production of the …

Considerable progress has been made in identifying the transcription factors involved in the
early specification of the B-lymphocyte lineage. However, little is known about factors that …

When unfolded proteins accumulate in the endoplasmic reticulum (ER), transcription of
glucose-regulated proteins (GRPs) representing ER-resident molecular chaperones is …

Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …

Plasma cells are the terminally differentiated, non-dividing effector cells of the B-cell lineage.
They are cellular factories devoted to the task of synthesizing and secreting thousands of …

Transcription of genes encoding molecular chaperones and folding enzymes in the
endoplasmic reticulum (ER) is induced by accumulation of unfolded proteins in the ER. This …