The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
D Klatzmann, AK Abbas - Nature Reviews Immunology, 2015 - nature.com
Depletion of regulatory T (TReg) cells in otherwise healthy individuals leads to multi-organ
autoimmune disease and inflammation. This indicates that in a normal immune system …
autoimmune disease and inflammation. This indicates that in a normal immune system …
Lymphopenia in cancer patients and its effects on response to immunotherapy: an opportunity for combination with cytokines?
Quantitative lymphocyte alterations are frequent in patients with cancer, and strongly impact
prognosis and survival. The development of cancers in immunosuppressed patients has …
prognosis and survival. The development of cancers in immunosuppressed patients has …
The split personality of regulatory T cells in HIV infection
MF Chevalier, L Weiss - Blood, The Journal of the American …, 2013 - ashpublications.org
Natural regulatory T cells (Tregs) participate in responses to various chronic infections
including HIV. HIV infection is associated with a progressive CD4 lymphopenia and …
including HIV. HIV infection is associated with a progressive CD4 lymphopenia and …
Protective HIV-specific CD8+ T cells evade Treg cell suppression
Specific human leukocyte antigens (HLAs), notably HLA-B* 27 and HLA-B* 57 allele groups,
have long been associated with control of HIV-1. Although the majority of HIV-specific CD8+ …
have long been associated with control of HIV-1. Although the majority of HIV-specific CD8+ …
Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa …
Background. The immune deficiency of human immunodeficiency virus (HIV) infection is not
fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but …
fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but …
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
Emerging evidence demonstrates that adaptive immunity influences the pathobiology of
neurodegenerative disorders. Misfolded aggregated self-proteins can break immune …
neurodegenerative disorders. Misfolded aggregated self-proteins can break immune …
Trial Watch: Chemotherapy with immunogenic cell death inducers
Accumulating evidence suggests that the clinical efficacy of selected anticancer drugs,
including conventional chemotherapeutics as well as targeted anticancer agents, originates …
including conventional chemotherapeutics as well as targeted anticancer agents, originates …
Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients
M Manuel, O Trédan, T Bachelot, G Clapisson… - …, 2012 - Taylor & Francis
Lymphopenia (< 1Giga/L) detected before initiation of chemotherapy is a predictive factor for
death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was …
death in metastatic solid tumors. Combinatorial T cell repertoire (TCR) diversity was …
Lymphoid tissue structure and HIV-1 infection: life or death for T cells
M Zeng, AT Haase, TW Schacker - Trends in immunology, 2012 - cell.com
Secondary lymphoid tissue (LT) structure facilitates immune responses and maintains
homeostasis of T cells through production of survival factors, such as interleukin (IL)-7 that is …
homeostasis of T cells through production of survival factors, such as interleukin (IL)-7 that is …
Dietary Supplementation With High Doses of Regular Vitamin D3 Safely Reduces Diabetes Incidence in NOD Mice When Given Early and Long Term
T Takiishi, L Ding, F Baeke, I Spagnuolo… - Diabetes, 2014 - Am Diabetes Assoc
High doses of the active form of vitamin D3, 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3],
prevent diabetes in the NOD mouse but also elicit unwanted calcemic side effects. Because …
prevent diabetes in the NOD mouse but also elicit unwanted calcemic side effects. Because …