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Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
Ecology and genomics of Actinobacteria: new concepts for natural product discovery
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
[HTML][HTML] Marine bacterial secondary metabolites: A treasure house for structurally unique and effective antimicrobial compounds
The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs
in preventing and treating infectious diseases caused by pathogenic organisms, such as …
in preventing and treating infectious diseases caused by pathogenic organisms, such as …
Chemical ecology of antibiotic production by actinomycetes
Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …
products relevant for agriculture, biotechnology and medicine, including the majority of the …
[HTML][HTML] Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects
Abstract Background Acetylcholinesterase (AChE), a serine hydrolase, is primarily
responsible for the termination of signal transmission in the cholinergic system, owing to its …
responsible for the termination of signal transmission in the cholinergic system, owing to its …
Fungal endophytes for sustainable crop production
This minireview highlights the importance of endophytic fungi for sustainable agriculture and
horticulture production. Fungal endophytes play a key role in habitat adaptation of plants …
horticulture production. Fungal endophytes play a key role in habitat adaptation of plants …
Current approaches and challenges for the metabolite profiling of complex natural extracts
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …
research. Obtaining precise information on the chemical composition of complex natural …
Enhancing chemical and biological diversity by co-cultivation
In natural product research, microbial metabolites have tremendous potential to provide new
therapeutic agents since extremely diverse chemical structures can be found in the nearly …
therapeutic agents since extremely diverse chemical structures can be found in the nearly …
Dietary amino acids and the gut‐microbiome‐immune axis: physiological metabolism and therapeutic prospects
Dietary amino acids (AAs) are not only absorbed and metabolized by enterocytes but also
available to the microbiota in the gut in mammals. In addition to serving as the materials for …
available to the microbiota in the gut in mammals. In addition to serving as the materials for …
Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters
Microorganisms form diverse multispecies communities in various ecosystems. The high
abundance of fungal and bacterial species in these consortia results in specific …
abundance of fungal and bacterial species in these consortia results in specific …