TMEM proteins in cancer: a review

K Schmit, C Michiels - Frontiers in pharmacology, 2018 - frontiersin.org
A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

Role of DNA methylation in the resistance to therapy in solid tumors

S Romero-Garcia, H Prado-Garcia… - Frontiers in …, 2020 - frontiersin.org
Despite the recent advances in chemotherapeutic treatments against cancer, some types of
highly aggressive and invasive cancer develop drug resistance against conventional …

Epigenetics in ovarian cancer

Y Natanzon, EL Goode, JM Cunningham - Seminars in cancer biology, 2018 - Elsevier
Ovarian cancer is a disease with a poor prognosis and little progress has been made to
improve treatment. It is now recognized that there are several histotypes of ovarian cancer …

Epigenetic biomarkers in the management of ovarian cancer: current prospectives

A Singh, S Gupta, M Sachan - Frontiers in cell and developmental …, 2019 - frontiersin.org
Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …

Platinum-resistant ovarian cancer: From drug resistance mechanisms to liquid biopsy-based biomarkers for disease management

MA Khan, KS Vikramdeo, SK Sudan, S Singh… - Seminars in cancer …, 2021 - Elsevier
Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer,
contributing to the high mortality-to-incidence ratio. Management of the platinum-resistant …

TMEM119 facilitates ovarian cancer cell proliferation, invasion, and migration via the PDGFRB/PI3K/AKT signaling pathway

T Sun, F Bi, Z Liu, Q Yang - Journal of translational medicine, 2021 - Springer
Background Ovarian cancer (OV) is the deadliest gynecological cancer. Transmembrane
protein 119 (TMEM119) has been reported as oncogene in several human cancers …

TMEM196 inhibits lung cancer metastasis by regulating the Wnt/β-catenin signaling pathway

J Chen, D Wang, H Chen, J Gu, X Jiang, F Han… - Journal of Cancer …, 2023 - Springer
Purpose The TMEM196 protein, which comprises four membrane-spanning domains,
belongs to the TMEM protein family. TMEM196 was identified as a candidate tumor …

Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer

L Feng, B Yan, Y Huang, L Li - Clinical Epigenetics, 2021 - Springer
Background Primary or acquired chemoresistance is a key link in the high mortality rate of
ovarian cancer. There is no reliable method to predict chemoresistance in ovarian cancer …

Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis

L Yin, Y Wang - Cancer cell international, 2021 - Springer
Abstract Background/Aim Growing evidence indicates a significant role of long non-coding
RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in ovarian cancer, a …

Methylation and ovarian cancer: Can DNA methylation be of diagnostic use?

JL Hentze, CK Høgdall… - … and clinical oncology, 2019 - spandidos-publications.com
Ovarian cancer is a silent killer and, due to late diagnosis and frequent chemo resistance in
patients, the primary cause of fatality amongst the various types of gynecological cancer …