With an increasingly aging society, bone defects and fractures have become significant
threats to human health and quality of life. Currently, autologous and allogeneic bone grafts …

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to
conventional cancer treatment regimens. Its effective use as a cancer therapy requires a …

Engineering a proper immune response following biomaterial implantation is essential to
bone tissue regeneration. Herein, a biomimetically hierarchical scaffold composed of …

Although growth factor (GF)‐loaded hydrogels have been explored as promising materials
in repairing bone defects, it still remains challenging to construct smart hydrogels with …

The treatment of bone defects remains a significant challenge to be solved clinically.
Immunomodulatory properties of orthopedic biomaterials have significance in regulating …

Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown
potential as an effective therapeutic tool for repairing bone defects. Although metal-organic …

Large-sized bone defects are a great challenge in clinics and considerably impair the quality
of patients' daily life. Tissue engineering strategies using cells, scaffolds, and bioactive …

Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack
of effective treatments in clinic. Stem cell transplantation has emerged as an alternative …

Regeneration the critical-sized bone defects remains a great challenge to clinical therapy
due to the inflammatory microenvironment and lack of stem cells in the region of the bone …

Wound healing is a highly orchestrated process involving a variety of cells, including
immune cells. Develo** immunomodulatory biomaterials for regenerative engineering …