After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

Administration of drugs through oral and intravenous routes is a mainstay of modern
medicine, but this approach suffers from limitations associated with off-target side effects and …

Lipid-shelled microbubbles have received extensive interest to enhance ultrasound-
responsive drug delivery outcomes due to their high biocompatibility. While therapeutic …

Gas‐filled microbubbles (MBs) have been clinically used as ultrasound (US) contrast agents
for disease diagnosis and treatment. However, it remains a great challenge to resolve the …

The structural complexity of the brain hinders the traditional treatment of brain diseases from
achieving desirable outcomes, which urges the research and development of multiple …

Carbon monoxide (CO) is a gaseous signaling molecule that modulates inflammation, cell
survival, and recovery after myocardial infarction. However, handling and dosing of CO as a …

Low tissue oxygenation significantly impairs the effectiveness of cancer therapy and
promotes a more aggressive phenotype. Many strategies to improve tissue oxygenation …

Early lesion site diagnosis and neuroprotection are crucial to the theranostics of acute
ischemic stroke. Xenon (Xe), as a nontoxic gaseous neuroprotectant, holds great promise for …

Inhalation of xenon gas improves acute kidney injury (AKI). However, xenon can only be
delivered through inhalation, which causes non‐specific distribution and low bioavailability …

Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being
tested as a means to locally deliver drugs into the brain. Such FUS therapies require …