Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …

Naturally occurring plasmids come in different sizes. The smallest are less than a kilobase of
DNA, while the largest can be over three orders of magnitude larger. Historically, research …

Insertion sequence (IS) elements are the simplest autonomous transposable elements found
in prokaryotic genomes. We recently discovered that IS110 family elements encode a …

Motivation The insertion sequence (IS) elements are the smallest but most abundant
autonomous transposable elements in prokaryotic genomes, which play a key role in …

Antimicrobial resistance (AMR) is a significant global threat to both public health and the
environment. The emergence and expansion of AMR is sustained by the enormous diversity …

The majority of eukaryotic genomes contain a large fraction of repetitive sequences that
primarily originate from transpositional bursts of transposable elements (TEs). Repbase …

Bacterial genomes encode numerous homologs of Cas9, the effector protein of the type II
CRISPR-Cas systems. The homology region includes the arginine-rich helix and the HNH …

The relationships within a curated set of 112 insertion sequences (ISs) currently assigned to
the IS 6 family, here re-named the IS 6/IS 26 family, in the ISFinder database were …

The dissemination of antibiotic resistance genes (ARGs) driven by mobile genetic elements
(MGEs), especially among pathogenic bacteria, is of increasing global concern. Different …

The bla NDM-1 gene encodes a carbapenemase that confers resistance to almost all β-
lactams, including last-resort carbapenems. This is increasingly reported worldwide in …