The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors

Q Wei, P Li, T Yang, J Zhu, L Sun, Z Zhang… - Journal of Hematology & …, 2024 - Springer
Antibody-drug conjugates (ADCs) represent an important class of cancer therapies that have
revolutionized the treatment paradigm of solid tumors. To date, many ongoing studies of …

Focal adhesion kinase: from biological functions to therapeutic strategies

X Tan, Y Yan, B Song, S Zhu, Q Mei, K Wu - Experimental Hematology & …, 2023 - Springer
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

POP1 facilitates proliferation in triple-negative breast cancer via m6A-Dependent degradation of CDKN1A mRNA

C Zhang, S Wang, X Lu, W Zhong, Y Tang, W Huang… - Research, 2024 - spj.science.org
Triple-negative breast cancer (TNBC) is currently the worst prognostic subtype of breast
cancer, and there is no effective treatment other than chemotherapy. Processing of …

“Triple-Punch” Strategy Exosome-Mimetic Nanovesicles for Triple Negative Breast Cancer Therapy

C Zhang, S Tang, M Wang, L Li, J Li, D Wang, X Mi… - ACS …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) is the most malignant breast cancer, with high rates of
relapse and metastasis. Because of the nonspecific targeting of chemotherapy and …

The role of immune checkpoint inhibition in triple negative breast cancer

K Tarekegn, M Keskinkilic, TJ Kristoff… - Expert Review of …, 2023 - Taylor & Francis
Introduction Immunotherapy has revolutionized cancer treatment, including TNBC, which
has limited options of treatment and poor prognosis. ICIs studied in TNBC include …

[HTML][HTML] Advances in siRNA Drug Delivery Strategies for Targeted TNBC Therapy

MA Subhan, VP Torchilin - Bioengineering, 2024 - mdpi.com
Among breast cancers, triple-negative breast cancer (TNBC) has been recognized as the
most aggressive type with a poor prognosis and low survival rate. Targeted therapy for …

Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021

T Li, H Zhang, M Lian, Q He, M Lv, L Zhai… - Journal of Hematology & …, 2025 - Springer
Female-specific cancers, particularly breast, cervical, ovarian, and uterine cancers, account
for nearly 40% of all cancers in women. This study aimed to analyze the global …

The treatment landscape of triple-negative breast cancer

Y Hu, C Wang, H Liang, J Li, Q Yang - Medical Oncology, 2024 - Springer
Triple-negative breast cancer (TNBC) tumors are biologically aggressive breast cancer. On
the molecular level, TNBC is a highly heterogeneous disease; more biotechnologies are …

Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities

H Tiwari, S Singh, S Sharma, P Gupta… - Medicinal Research …, 2024 - Wiley Online Library
Triple negative breast cancer (TNBC) displays a notable challenge in clinical oncology due
to its invasive nature which is attributed to the absence of progesterone receptor (PR) …

Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity

C Mao, J Fang, S Zou, Y Huang, X Chen… - Journal of Medicinal …, 2024 - ACS Publications
Triple-negative breast cancer (TNBC) represents a highly aggressive and heterogeneous
malignancy. Currently, multitarget drug approaches present a promising therapeutic …