Challenges of neuropathic pain: focus on diabetic neuropathy

DC Rosenberger, V Blechschmidt… - Journal of Neural …, 2020 - Springer
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Neuropathic pain: central vs. peripheral mechanisms

K Meacham, A Shepherd, DP Mohapatra… - Current pain and …, 2017 - Springer
Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

The role and pharmacological properties of the P2X7 receptor in neuropathic pain

W Zhang, Z Zhu, Z Liu - Brain Research Bulletin, 2020 - Elsevier
Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is
a common symptom of many diseases. Clinically, drugs are usually used to suppress pain …

The core of maintaining neuropathic pain: crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

T Zhang, M Zhang, S Cui, W Liang, Z Jia… - Brain and …, 2023 - Wiley Online Library
Background Neuropathic pain (NP) caused by the injury or dysfunction of the nervous
system is a chronic pain state accompanied by hyperalgesia, and the available clinical …

Vesicular glutamate transporter isoforms: the essential players in the somatosensory systems

FX Zhang, SN Ge, YL Dong, J Shi, YP Feng, Y Li… - Progress in …, 2018 - Elsevier
In nervous system, glutamate transmission is crucial for centripetal conveyance and cortical
perception of sensory signals of different modalities, which necessitates vesicular glutamate …

Loss of M1 receptor dependent cholinergic excitation contributes to mPFC deactivation in neuropathic pain

D Radzicki, SL Pollema-Mays… - Journal of …, 2017 - Soc Neuroscience
In chronic pain, the medial prefrontal cortex (mPFC) is deactivated and mPFC-dependent
tasks such as attention and working memory are impaired. We investigated the mechanisms …

The role of miR-190a-5p contributes to diabetic neuropathic pain via targeting SLC17A6

D Yang, Q Yang, X Wei, Y Liu, D Ma, J Li… - Journal of pain …, 2017 - Taylor & Francis
Introduction MicroRNAs play a key role in neuropathic pain. In a previous study, miR-190a-
5p was significantly downregulated in diabetic neuropathic pain (DNP). However, the role …

[PDF][PDF] Physiology and pharmacology of neurotransmitter transporters

N Ayala-Lopez, SW Watts - Compr. Physiol, 2021 - researchgate.net
Regulation of the ability of a neurotransmitter [our focus: serotonin, norepinephrine,
dopamine, acetylcholine, glycine, and gamma-aminobutyric acid (GABA)] to reach its …

Synaptamide improves cognitive functions and neuronal plasticity in neuropathic pain

A Tyrtyshnaia, A Bondar, S Konovalova… - International journal of …, 2021 - mdpi.com
Neuropathic pain arises from damage or dysfunction of the peripheral or central nervous
system and manifests itself in a wide variety of sensory symptoms and cognitive disorders …

CSB6B prevents β-amyloid-associated neuroinflammation and cognitive impairments via inhibiting NF-κB and NLRP3 in microglia cells

S Yan, Z Xuan, M Yang, C Wang, T Tao, Q Wang… - International …, 2020 - Elsevier
Pathological β-amyloid (Aβ)-induced microglial activation could cause chronic
neuroinflammation in the brain of Alzheimer's disease (AD) patients, and has been …