Drugging p53 in cancer: one protein, many targets
Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …
[HTML][HTML] p53 and metabolism: from mechanism to therapeutics
The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
Oxidative stress and redox-dependent signaling in prostate cancer
Tumor emergence and progression is complicated by the dual role of reactive oxygen
species (ROS). Low concentrations of ROS are essential for many intracellular metabolic …
species (ROS). Low concentrations of ROS are essential for many intracellular metabolic …
A mini-review of reactive oxygen species in urological cancer: correlation with NADPH oxidases, angiogenesis, and apoptosis
Y Miyata, T Matsuo, Y Sagara, K Ohba… - International journal of …, 2017 - mdpi.com
Oxidative stress refers to elevated reactive oxygen species (ROS) levels, and NADPH
oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress …
oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress …
Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines
There is a common agreement on the important role of the gastrointestinal microbiota in the
etiology of cancer. Benign probiotic yeast strains are able to ameliorate intestinal microbiota …
etiology of cancer. Benign probiotic yeast strains are able to ameliorate intestinal microbiota …
Anticancer properties of red beetroot hydro-alcoholic extract and its main constituent; betanin on colorectal cancer cell lines
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Red beetroot
(Beta vulgaris) contains Betanin as its major betacyanin, possessing wide proapoptotic …
(Beta vulgaris) contains Betanin as its major betacyanin, possessing wide proapoptotic …
[HTML][HTML] The use of adenoviral vectors in gene therapy and vaccine approaches
NM Araújo, IGS Rubio, NPA Toneto… - … and Molecular Biology, 2022 - SciELO Brasil
Adenovirus was first identified in the 1950s and since then this pathogenic group of viruses
has been explored and transformed into a genetic transfer vehicle. Modification or deletion …
has been explored and transformed into a genetic transfer vehicle. Modification or deletion …
Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth
For patients with metastatic prostate cancer, the 5-year survival rate of 31% points to a need
for novel therapies and improvement of existing modalities. We propose that p53 gene …
for novel therapies and improvement of existing modalities. We propose that p53 gene …
Oncolytic adenovirus rAd. DCN inhibits breast tumor growth and lung metastasis in an immune-competent orthotopic xenograft model
H Zhao, H Wang, F Kong, W Xu, T Wang… - Human Gene …, 2019 - liebertpub.com
The majority of advanced breast cancer patients develop distal metastasis, including lung
and bone metastasis. However, effective therapeutic strategies to prevent metastasis are still …
and bone metastasis. However, effective therapeutic strategies to prevent metastasis are still …
Oxidative stress mediates hippocampal neuronal apoptosis through ROS/JNK/P53 pathway in rats with PTSD triggered by high-voltage electrical burn
Y Lv, X Zhao, R Zhang, Z He, Y Xu, L Tu… - Folia …, 2024 - journals.viamedica.pl
Background: The pathogenesis of post-traumatic stress disorder (PTSD) triggered by high-
voltage electrical burn (HVEB) remains unclear and the oxidative stress plays a role in this …
voltage electrical burn (HVEB) remains unclear and the oxidative stress plays a role in this …