Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

One of the key drivers for successful metabolic engineering in microbes is the efficacy by
which genomes can be edited. As such there are many methods to choose from when …

Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary
metabolites with many medicinal properties, including the essential anti-cancer therapeutics …

Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

Saccharomyces cerevisiae is an increasingly attractive host for synthetic biology because of
its long history in industrial fermentations. However, until recently, most synthetic biology …

CRISPR/Cas9 is a simple and efficient tool for targeted and marker-free genome
engineering. Here, we report the development and successful application of a multiplex …

Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 technology is an
important tool for genome editing because the Cas9 endonuclease can induce targeted …

Resveratrol is a natural antioxidant compound, used as food supplement and cosmetic
ingredient. Microbial production of resveratrol has until now been achieved by …

Resveratrol is a plant secondary metabolite with multiple health-beneficial properties.
Microbial production of resveratrol in model microorganisms requires extensive engineering …

Aromatic amino acids are precursors of numerous plant secondary metabolites with diverse
biological functions. Many of these secondary metabolites are already being used as active …