Promising Acinetobacter baumannii Vaccine Candidates and Drug Targets in Recent Years

YC Tan, C Lahiri - Frontiers in immunology, 2022 - frontiersin.org
In parallel to the uncontrolled use of antibiotics, the emergence of multidrug-resistant
bacteria, like Acinetobacter baumannii, has posed a severe threat. A. baumannii …

Non-antibiotic prevention and treatment against Acinetobacter baumannii infection: Are vaccines and adjuvants effective strategies?

Y Hu, X Zhang, S Deng, C Yue, X Jia… - Frontiers in Microbiology, 2023 - frontiersin.org
Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely
attached to the surface of medical instruments, making it one of the most common pathogens …

Acinetobacter baumannii subunit vaccines: recent progress and challenges

YT Lau, HS Tan - Critical reviews in microbiology, 2024 - Taylor & Francis
Acinetobacter baumannii is a Gram-negative, opportunistic pathogen that causes
nosocomial infection with a high mortality rate in immunocompromised individuals. With the …

Vaccine development to control the rising scourge of antibiotic-resistant Acinetobacter baumannii: a systematic review

R Singh, N Capalash, P Sharma - 3 Biotech, 2022 - Springer
Acinetobacter baumannii has emerged as one of major nosocomial pathogen and global
emergence of multidrug-resistant strains has become a challenge for develo** effective …

Construction of an aerolysin-based multi-epitope vaccine against Aeromonas hydrophila: an in silico machine learning and artificial intelligence-supported approach

AS Alawam, MS Alwethaynani - Frontiers in Immunology, 2024 - frontiersin.org
Aeromonas hydrophila, a gram-negative coccobacillus bacterium, can cause various
infections in humans, including septic arthritis, diarrhea (traveler's diarrhea), gastroenteritis …

Pan-Genome Reverse Vaccinology Approach for the Design of Multi-Epitope Vaccine Construct against Escherichia albertii

K Jalal, K Khan, D Ahmad, A Hayat, Z Basharat… - International Journal of …, 2021 - mdpi.com
Escherichia albertii is characterized as an emerging pathogen, causing enteric infections. It
is responsible for high mortality rate, especially in children, elderly, and …

Structural diversity among Acinetobacter baumannii K-antigens and its implication in the in silico seroty**

J Roshini, LPP Patro, S Sundaresan… - Frontiers in …, 2023 - frontiersin.org
Acinetobacter baumannii is an emerging opportunistic pathogen. It exhibits multi-, extreme-,
and pan-drug resistance against several classes of antibiotics. Capsular polysaccharide …

In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds

TV Denysko, OA Nazarchuk, O Gruzevskyi… - Frontiers in …, 2022 - frontiersin.org
Healthcare-associated infections (HCAIs) are among the most prominent medical problems
worldwide. In the context of increasing antibiotic resistance globally, the use of antiseptics as …

Immunoinformatics Approach Toward the Introduction of a Novel Multi-Epitope Vaccine Against Clostridium difficile

C Tan, F Zhu, Y **ao, Y Wu, X Meng, S Liu… - Frontiers in …, 2022 - frontiersin.org
Clostridium difficile (C. difficile) is an exclusively anaerobic, spore-forming, and Gram-
positive pathogen that is the most common cause of nosocomial diarrhea and is becoming …

Modern vaccine development via reverse vaccinology to combat antimicrobial resistance

AJ Tobuse, CW Ang, KY Yeong - Life Sciences, 2022 - Elsevier
With the continuous evolution of bacteria, the global antimicrobial resistance health threat is
causing millions of deaths yearly. While depending on antibiotics as a primary treatment has …