Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …
been extensively researched since the landmark report by Morpurgo (1897) of “work …
Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies
Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …
most dynamic and plastic tissues in the human body and plays a vital role in movement …
Mechanisms underlying sensing of cellular stress signals by mammalian MAP3 kinases
K Mordente, L Ryder, S Bekker-Jensen - Molecular Cell, 2024 - cell.com
Cellular homeostasis is continuously challenged by environmental cues and cellular stress
conditions. In their defense, cells need to mount appropriate stress responses that …
conditions. In their defense, cells need to mount appropriate stress responses that …
The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth
S Edman, RG Jones III, PR Jannig… - EMBO …, 2024 - embopress.org
A detailed understanding of molecular responses to a hypertrophic stimulus in skeletal
muscle leads to therapeutic advances aimed at promoting muscle mass. To decode the …
muscle leads to therapeutic advances aimed at promoting muscle mass. To decode the …
[HTML][HTML] Complex II ambiguities—FADH2 in the electron transfer system
E Gnaiger - Journal of Biological Chemistry, 2024 - Elsevier
The prevailing notion that reduced cofactors NADH and FADH 2 transfer electrons from the
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …
tricarboxylic acid cycle to the mitochondrial electron transfer system creates ambiguities …
Methylome–proteome integration after late‐life voluntary exercise training reveals regulation and target information for improved skeletal muscle health
Exercise is a potent stimulus for combatting skeletal muscle ageing. To study the effects of
exercise on muscle in a preclinical setting, we developed a combined endurance …
exercise on muscle in a preclinical setting, we developed a combined endurance …
GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels
Muscle stem cells (MuSCs) enable muscle growth and regeneration after exercise or injury,
but how metabolism controls their regenerative potential is poorly understood. We describe …
but how metabolism controls their regenerative potential is poorly understood. We describe …
The 75-Year Anniversary of the Department of Physiology and Pharmacology at Karolinska Institutet—Examples of Recent Accomplishments and Future Perspectives
E Weitzberg, M Ingelman-Sundberg… - Pharmacological …, 2024 - Elsevier
Karolinska Institutet is a medical university encompassing 21 departments distributed across
three departmental or campus groups. Pharmacological research has a long and successful …
three departmental or campus groups. Pharmacological research has a long and successful …
Mitochondria as nutritional targets to maintain muscle health and physical function during ageing
The age-related loss of skeletal muscle mass and physical function leads to a loss of
independence and an increased reliance on health-care. Mitochondria are crucial in the …
independence and an increased reliance on health-care. Mitochondria are crucial in the …
Identification of Genomic Predictors of Muscle Fiber Size
JPLF Guilherme, EA Semenova, N Kikuchi, H Homma… - Cells, 2024 - pmc.ncbi.nlm.nih.gov
The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal
muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of …
muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of …