ROS: Basic concepts, sources, cellular signaling, and its implications in aging pathways
AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
Arterial stiffness and cardiovascular risk in hypertension
P Boutouyrie, P Chowienczyk, JD Humphrey… - Circulation …, 2021 - ahajournals.org
Arterial stiffness, a leading marker of risk in hypertension, can be measured at material or
structural levels, with the latter combining effects of the geometry and composition of the …
structural levels, with the latter combining effects of the geometry and composition of the …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …
humans. Despite more than a century of research, hypertension remains difficult to cure due …
[HTML][HTML] Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as
frequent in patients with diabetes compared with those who do not have diabetes. Moreover …
frequent in patients with diabetes compared with those who do not have diabetes. Moreover …
A role for advanced glycation end products in molecular ageing
K Zgutka, M Tkacz, P Tomasiak… - International journal of …, 2023 - mdpi.com
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ
and whole-body levels. These changes result in decreased functioning of the organism and …
and whole-body levels. These changes result in decreased functioning of the organism and …
[HTML][HTML] Oxidative stress: a unifying paradigm in hypertension
The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …
and pathophysiologic factors that influence many regulatory systems. Hypertension is …
The role of vascular smooth muscle cells in arterial remodeling: focus on calcification-related processes
Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …
Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension
IAM Brown, L Diederich, ME Good… - … , and vascular biology, 2018 - ahajournals.org
Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …
[HTML][HTML] Effect of different classes of antihypertensive drugs on endothelial function and inflammation
IVG Silva, RC de Figueiredo, DRA Rios - International journal of …, 2019 - mdpi.com
Hypertension is characterized by structural and functional changes in blood vessels that
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …