P. aeruginosa is still one of the most threatening pathogens responsible for serious hospital-
acquired infections. It is intrinsically resistant to many antimicrobial agents and additional …

Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

Enterobacterales resistant to carbapenems or producing extended-spectrum β-lactamases
(ESBL) and non-fermenters resistant to carbapenems present resistance to many of the …

ABSTRACT Introduction Carbapenem-resistant (CR) Pseudomonas aeruginosa infections
constitute a serious clinical threat globally. Patients are often critically ill and/or …

Infections caused by ceftolozane-tazobactam and ceftazidime-avibactam-resistant P.
aeruginosa infections are an emerging concern. We aimed to analyze the underlying …

Objectives To evaluate the activity of cefiderocol, imipenem/relebactam, cefepime/
taniborbactam and cefepime/zidebactam against a clinical and laboratory collection of …

ABSTRACT Ceftolozane-tazobactam (C/T), imipenem-relebactam (IMR), and ceftazidime-
avibactam (CZA) were tested against 2,531 P. aeruginosa strains isolated from patients in …

The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the
interest of researchers for decades because of its therapeutic implications, since it is …

Objectives To analyse the dynamics and mechanisms of stepwise resistance development
to cefiderocol in Pseudomonas aeruginosa. Methods Cefiderocol resistance evolution was …

Scope Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen considered one of
the paradigms of antimicrobial resistance, is among the main causes of hospital-acquired …