Mechanistic basis for multidrug resistance and collateral drug sensitivity conferred to the malaria parasite by polymorphisms in PfMDR1 and PfCRT

SH Shafik, SN Richards, B Corry, RE Martin - PLoS biology, 2022 - journals.plos.org
Polymorphisms in the Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene
and the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene alter the …

Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination

HG Ngassa Mbenda, M Wang, J Guo, FA Siddiqui… - Parasites & vectors, 2020 - Springer
Background The malaria elimination plan of the Greater Mekong Subregion (GMS) is
jeopardized by the increasing number of Plasmodium vivax infections and emergence of …

Monitoring PfMDR1 transport in Plasmodium falciparum

SJ Reiling, P Rohrbach - Malaria Journal, 2015 - Springer
Abstract Background The Plasmodium falciparum multidrug resistance 1 transporter,
PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in …

Therapeutic potential of Stigmasterol and Kaempferol on multidrug-resistant malaria

IA Taiwo, SO Oyejide - 2024 - nopr.niscpr.res.in
Falciparum malaria is the most common form of malaria in Nigeria and other countries
where the disease is endemic. Increasing cases of multidrug-resistant falciparum malaria is …

Genotypes and phenotypes of resistance in Ecuadorian Plasmodium falciparum

G Valenzuela, LE Castro, J Valencia-Zamora… - Malaria Journal, 2019 - Springer
Background Malaria continues to be endemic in the coast and Amazon regions of Ecuador.
Clarifying current Plasmodium falciparum resistance in the country will support malaria …

Assessing the Antimalarial Potentials of Phytochemicals: Virtual Screening, Molecular Dynamics and In-Vitro Investigations

SK Patel, M Athar, PC Jha, VM Khedkar… - Letters in Drug …, 2019 - benthamdirect.com
Background: Combined in-silico and in-vitro approaches were adopted to investigate the
antiplasmodial activity of Catharanthus roseus and Tylophora indica plant extracts as well as …

200 Structural insights into the theoretical model of Plasmodium falciparum multi drug resistance 1 protein (PfMDR1) and its interaction with phytochemicals as efficacious antimalarial …

SK Patel, PC Jha, Y Jasrai, HA Pandya… - Journal of Biomolecular …, 2015 - Taylor & Francis
200 Structural insights into the theoretical model of Plasmodium falciparum multi drug resistance 1
protein (PfMDR1) and its int Page 1 200Structural insights into the theoretical model of …

[KNIHA][B] Analysis of drug resistance mechanisms in intact Plasmodium falciparum-infected red blood cells

SJ Reiling - 2015 - search.proquest.com
Malaria is a major global health concern, with half of the world's population being at risk of
infection. Among the Plasmodium species that infect humans, P. falciparum causes most …