Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

Posttranslational modifications of histone N-terminal tails impact chromatin structure and
gene transcription. While the extent of histone acetylation is determined by both …

X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

Cellular senescence is an extremely stable form of cell cycle arrest that limits the
proliferation of damaged cells and may act as a natural barrier to cancer progression. In this …

Enhancer of Zeste [E (z)] is a Polycomb-group transcriptional repressor and one of the
founding members of the family of SET domain-containing proteins. Several SET-domain …

Covalent modification of histone tails is crucial for transcriptional regulation, mitotic
chromosomal condensation, and heterochromatin formation. Histone H3 lysine 9 (H3-K9) …

Gene silencing in eukaryotes is associated with the formation of heterochromatin, a complex
of proteins and DNA that block transcription. Heterochromatin is characterized by the …

Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …