The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer
L Ding, J Cao, W Lin, H Chen, X **ong, H Ao… - International journal of …, 2020 - mdpi.com
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …
Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits of polyphenols: A comprehensive review
Polyphenols, including phenolics, alkaloids, and terpenes, are secondary metabolites that
are commonly found in fruits, vegetables, and beverages, such as tea, coffee, wine …
are commonly found in fruits, vegetables, and beverages, such as tea, coffee, wine …
The CDK4/6 inhibitor revolution—A game-changing era for breast cancer treatment
L Morrison, S Loibl, NC Turner - Nature Reviews Clinical Oncology, 2024 - nature.com
Abstract Cyclin-dependent kinase (CDK) 4/6 inhibition in combination with endocrine
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
Abstract Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
The pathogenesis of mixed-lineage leukemia
AG Muntean, JL Hess - Annual Review of Pathology …, 2012 - annualreviews.org
Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …
Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells
LH Swift, RM Golsteyn - International journal of molecular sciences, 2014 - mdpi.com
When a human cell detects damaged DNA, it initiates the DNA damage response (DDR) that
permits it to repair the damage and avoid transmitting it to daughter cells. Despite this …
permits it to repair the damage and avoid transmitting it to daughter cells. Despite this …
Acute myeloid leukemia
JE Rubnitz, B Gibson, FO Smith - Pediatric clinics of North America, 2008 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal
transformation of hematopoietic precursors through the acquisition of chromosomal …
transformation of hematopoietic precursors through the acquisition of chromosomal …
[HTML][HTML] An insight into the emerging role of cyclin-dependent kinase inhibitors as potential therapeutic agents for the treatment of advanced cancers
Cancer denotes a pathological manifestation that is characterized by hyperproliferation of
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …
Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK …
A series of 1-H-pyrazole-3-carboxamide derivatives have been designed and synthesized
that exhibit excellent FLT3 and CDK inhibition and antiproliferative activities. A structure …
that exhibit excellent FLT3 and CDK inhibition and antiproliferative activities. A structure …
Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors
Novel series of diphenyl-1H-pyrazoles (4a-g) and pyrazolo [3, 4-b] pyridines (5a-g and 7a-i)
were synthesized and evaluated for their antiproliferative activity against breast cancer cell …
were synthesized and evaluated for their antiproliferative activity against breast cancer cell …