There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

The secretome is defined as the set of molecules and biological factors that are secreted by
cells into the extracellular space. In the past decade, secretome-based therapies have …

Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

The human skeleton is a miracle of engineering, combining both toughness and light weight.
It does so because bones possess cellular mechanisms wherein external mechanical loads …

Cells in osteoclast and osteoblast lineages communicate with each other through cell–cell
contact, diffusible paracrine factors and cell–bone matrix interaction. Osteoclast–osteoblast …

Lack of physical activity causes bone loss and fractures not only in elderly people, but also
in bedridden patients or otherwise inactive youth. This is fast becoming one of the most …

US7976519B2 - Externally-applied patient interface system and method - Google Patents
US7976519B2 - Externally-applied patient interface system and method - Google Patents …

Proper development of the skeleton in utero and during growth requires mechanical
stimulation. Loading results in adaptive changes in bone that strengthen bone structure …

Bone tissue forms and is remodeled in response to the mechanical forces that it
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …