Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide.
Hyperuricemia is the fourth risk factor for atherosclerosis after hypertension, diabetes, and …

Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …

Pancreatic ductal adenocarcinoma (PDAC) cells maintain a high level of autophagy,
allowing them to thrive in an austere microenvironment. However, the processes through …

Effective strategies for hepatocellular carcinoma, which is the second leading cause of death
worldwide, remain limited. A growing body of emerging evidence suggests that ferroptosis …

Cancer-associated fibroblasts (CAF) are major contributors to pancreatic ductal
adenocarcinoma (PDAC) progression through protumor signaling and the generation of …

Ferroptosis has been implicated in the pathophysiological progression of a variety of
diseases. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of cellular …

Ferroptosis plays a critical role in LPS-induced acute lung injury and is modulated by
endoplasmic reticulum stress (ERS). As a typical ER stress-responsive protein, recently …