Killing mechanisms of chimeric antigen receptor (CAR) T cells
Effective adoptive T cell therapy (ACT) comprises the killing of cancer cells through the
therapeutic use of transferred T cells. One of the main ACT approaches is chimeric antigen …
therapeutic use of transferred T cells. One of the main ACT approaches is chimeric antigen …
CAR T-Cell-Based gene therapy for cancers: new perspectives, challenges, and clinical developments
Chimeric antigen receptor (CAR)-T cell therapy is a progressive new pillar in immune cell
therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell …
therapy for cancer. It has yielded remarkable clinical responses in patients with B-cell …
CAR-T cells: the long and winding road to solid tumors
MM D'Aloia, IG Zizzari, B Sacchetti, L Pierelli… - Cell death & …, 2018 - nature.com
Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next
generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the …
generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the …
Efficient TALEN-mediated gene knockout in livestock
Transcription activator-like effector nucleases (TALENs) are programmable nucleases that
join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc …
join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc …
A hyperactive piggyBac transposase for mammalian applications
DNA transposons have been widely used for transgenesis and insertional mutagenesis in
various organisms. Among the transposons active in mammalian cells, the moth-derived …
various organisms. Among the transposons active in mammalian cells, the moth-derived …
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Slee** Beauty gene transfer to treat multiple myeloma
S Prommersberger, M Reiser, J Beckmann, S Danhof… - Gene therapy, 2021 - nature.com
Clinical development of chimeric antigen receptor (CAR)-T-cell therapy has been enabled
by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and …
by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and …
The past, present, and future of non-viral CAR T cells
A Moretti, M Ponzo, CA Nicolette… - Frontiers in …, 2022 - frontiersin.org
Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology
that has revolutionized the way we conceive immunotherapy. The impressive clinical results …
that has revolutionized the way we conceive immunotherapy. The impressive clinical results …
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of …
H Torikai, A Reik, PQ Liu, Y Zhou… - Blood, The Journal …, 2012 - ashpublications.org
Clinical-grade T cells are genetically modified ex vivo to express a chimeric antigen receptor
(CAR) to redirect specificity to a tumor associated antigen (TAA) thereby conferring antitumor …
(CAR) to redirect specificity to a tumor associated antigen (TAA) thereby conferring antitumor …
Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology
M Kalos, CH June - Immunity, 2013 - cell.com
Adoptive T cell transfer for cancer and chronic infection is an emerging field that shows
promise in recent trials. Synthetic-biology-based engineering of T lymphocytes to express …
promise in recent trials. Synthetic-biology-based engineering of T lymphocytes to express …
LINE-1 elements in structural variation and disease
CR Beck, JL Garcia-Perez, RM Badge… - Annual review of …, 2011 - annualreviews.org
The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …
study and discovery of human transposable elements. It now is undeniable that …