Breast and prostate cancer: more similar than different
Breast cancer and prostate cancer are the two most common invasive cancers in women
and men, respectively. Although these cancers arise in organs that are different in terms of …
and men, respectively. Although these cancers arise in organs that are different in terms of …
[HTML][HTML] Versatile TPR domains accommodate different modes of target protein recognition and function
RK Allan, T Ratajczak - Cell stress and chaperones, 2011 - Elsevier
The tetratricopeptide repeat (TPR) motif is one of many repeat motifs that form structural
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …
domains in proteins that can act as interaction scaffolds in the formation of multi-protein …
Akt–RSK–S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases
A Moritz, Y Li, A Guo, J Villén, Y Wang, J MacNeill… - Science …, 2010 - science.org
Receptor tyrosine kinases (RTKs) activate pathways mediated by serine-threonine kinases,
such as the PI3K (phosphatidylinositol 3-kinase)–Akt pathway, the Ras–MAPK (mitogen …
such as the PI3K (phosphatidylinositol 3-kinase)–Akt pathway, the Ras–MAPK (mitogen …
HERV-K (HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease
O Hohn, K Hanke, N Bannert - Frontiers in oncology, 2013 - frontiersin.org
Retroviruses that have the ability to infect germ line cells can become an integral and
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …
inherited part of the host genome. About 8% of the human chromosomal DNA consists of …
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
F Claessens, S Denayer… - Nuclear receptor …, 2008 - journals.sagepub.com
Androgens control male sexual development and maintenance of the adult male phenotype.
They have very divergent effects on their target organs like the reproductive organs, muscle …
They have very divergent effects on their target organs like the reproductive organs, muscle …
Systematic review: association of polycystic ovary syndrome with metabolic syndrome and non‐alcoholic fatty liver disease
Aliment Pharmacol Ther 2011; 33: 801–814 Summary Background Polycystic ovary
syndrome (PCOS) is a common disorder for women of child‐bearing age and is associated …
syndrome (PCOS) is a common disorder for women of child‐bearing age and is associated …
Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development
Background: Epigenetic alterations are common in prostate cancer, yet how these
modifications contribute to carcinogenesis is poorly understood. We investigated whether …
modifications contribute to carcinogenesis is poorly understood. We investigated whether …
Deficiency of adipose aryl hydrocarbon receptor protects against diet-induced metabolic dysfunction through sexually dimorphic mechanisms
The molecular mechanisms underlying diet-induced obesity are complex and remain
unclear. The activation of the aryl hydrocarbon receptor (AhR), a xenobiotic sensor, by …
unclear. The activation of the aryl hydrocarbon receptor (AhR), a xenobiotic sensor, by …
The hinge region in androgen receptor control
L Clinckemalie, D Vanderschueren, S Boonen… - Molecular and cellular …, 2012 - Elsevier
The region between the DNA-binding domain and the ligand-binding domain of nuclear
receptors is termed the hinge region. Although this flexible linker is poorly conserved …
receptors is termed the hinge region. Although this flexible linker is poorly conserved …
[HTML][HTML] Expression of androgen receptor splice variants in clinical breast cancers
The importance of androgen receptor (AR) signaling is increasingly being recognized in
breast cancer, which has elicited clinical trials aimed at assessing the efficacy of androgen …
breast cancer, which has elicited clinical trials aimed at assessing the efficacy of androgen …