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Lipid metabolism and cancer
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …
Mechanisms and regulation of cholesterol homeostasis
Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …
cholesterol balance underlies not only cardiovascular disease but also an increasing …
Liver X receptors in lipid signalling and membrane homeostasis
Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …
Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In
particular, how cholesterol internalized from HDL is made available to the cell for storage or …
particular, how cholesterol internalized from HDL is made available to the cell for storage or …
Targeting SREBP-2-regulated mevalonate metabolism for cancer therapy
L Xue, H Qi, H Zhang, L Ding, Q Huang, D Zhao… - Frontiers in …, 2020 - frontiersin.org
Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
Nuclear receptors regulate gene expression in response to environmental cues, but the
molecular events governing the cell type specificity of nuclear receptors remain poorly …
molecular events governing the cell type specificity of nuclear receptors remain poorly …
Molecular pathways underlying cholesterol homeostasis
Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is
vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis …
vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis …
The ubiquitous role of ubiquitination in lipid metabolism
Lipids are essential molecules that play key roles in cell physiology by serving as structural
components, for storage of energy, and in signal transduction. Hence, efficient regulation …
components, for storage of energy, and in signal transduction. Hence, efficient regulation …
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal
cancer (CRC) initiation and progression through the serrated route are largely unknown …
cancer (CRC) initiation and progression through the serrated route are largely unknown …
Cholesterol metabolism in cancer and cell death
Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …