It has been 30 years since a'new'leukaemia termed adult T-cell leukaemia (ATL) was
described in Japan, and more than 25 years since the isolation of the retrovirus, human T …

The HTLV Tax protein is crucial for viral replication and for initiating malignant
transformation leading to the development of adult T-cell leukemia. Tax has been shown to …

The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription
from the viral promoter via association with the cellular basic leucine zipper factor cAMP …

Human T-cell lymphotropic virus type I (HTLV-I) is the etiologic agent of adult T-cell leukemia
(ATL), a rapidly progressing, clonal malignancy of CD4+ T lymphocytes. Fewer than one in …

Background Antisense transcription in retroviruses has been suggested for both HIV-1 and
HTLV-I, although the existence and coding potential of these transcripts remain …

The high dimensionality of global transcription profiles, the expression level of 20,000 genes
in a much small number of samples, presents challenges that affect the sensitivity and …

Human T-cell leukemia virus type I (HTLV-I) 1 causes adult T-cell leukemia (ATL)(1–3). The
virus is also associated with a neuropathy/myelopathy termed HTLV-associated myelopathy …

Human T‐cell leukemia virus type I (HTLV‐I) bZIP factor (HBZ) is a viral basic leucine zipper
protein that was originally described as a partner of cAMP response element binding protein …

The phosphatidylinositol-3-kinase (PI3K) and AKT (protein kinase B) signaling pathways
play an important role in regulating cell cycle progression and cell survival. In previous …