Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and
diabetes are major risk factors, and with an increasing aging and diabetic population, the …

The proteins of the human eye are highly susceptible to the formation of advanced glycation
end products (AGEs) from the reaction of sugars and carbonyl compounds. AGEs …

Ocular tissues possess a robust antioxidant defence system to minimize oxidative stress and
preserve tissue structure and function. Glutathione (GSH) is a powerful antioxidant and in …

Advanced glycation end products (AGEs) contribute to lens protein pigmentation and cross-
linking during aging and cataract formation. In vitro experiments have shown that ascorbate …

The human eye is constantly exposed to sunlight and artificial lighting. Exogenous sources
of reactive oxygen species (ROS) such as UV light, visible light, ionizing radiation …

Ascorbic acid (AA) is an essential micronutrient for man, with many biological roles. It is a
powerful antioxidant both directly via scavenging of reactive oxygen species and indirectly …

Quantitative metabolomic profiles of normal and cataractous human lenses were obtained
with the combined use of high-frequency nuclear magnetic resonance (NMR) and high …

Senile cataracts are associated with progressive oxidation, fragmentation, cross-linking,
insolubilization, and yellow pigmentation of lens crystallins. We hypothesized that the …

PURPOSE. Recent epidemiologic studies suggest that differential risk for cataract in different
areas of the lens may be related to intake of carotenoids, retinol, and tocopherol …

Proteins are susceptible to oxidation by reactive oxygen species, where the type of damage
induced is characteristic of the denaturing species. The induction of protein carbonyls is a …