Cytokines function as communication tools of the immune system, serving critical functions
in many biological responses and sha** the immune response. When cytokine production …

Kinome-wide profiling platforms have comprehensively identified the relevant kinases that
are targeted by numerous protein kinase inhibitors. However, recent projects have begun to …

Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of
numerous cytokines and growth factors involved in the regulation of immunity, inflammation …

Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-
inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and …

PF-06651600, a newly discovered potent JAK3-selective inhibitor, is highly efficacious at
inhibiting γc cytokine signaling, which is dependent on both JAK1 and JAK3. PF-06651600 …

Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various
inflammatory diseases such as rheumatoid arthritis (RA). JAK inhibitors function …

Significant work has been dedicated to the discovery of JAK kinase inhibitors resulting in
several compounds entering clinical development and two FDA approved NMEs. However …

Janus kinases (JAKs) are a family of cytoplasmatic tyrosine kinases that are attractive targets
for the development of anti-inflammatory drugs given their roles in cytokine signaling. One …

RIP2 kinase is a central component of the innate immune system and enables downstream
signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading …

Demonstrating intracellular protein target engagement is an essential step in the
development and progression of new chemical probes and potential small molecule …