Critical review on anti‐inflammation effects of saponins and their molecular mechanisms

T Wijesekara, J Luo, B Xu - Phytotherapy Research, 2024 - Wiley Online Library
This review highlights the increasing interest in one of the natural compounds called
saponins, for their potential therapeutic applications in addressing inflammation which is a …

The “root” causes behind the anti-inflammatory actions of ginger compounds in immune cells

K Pázmándi, AG Szöllősi, T Fekete - Frontiers in Immunology, 2024 - frontiersin.org
Ginger (Zingiber officinale) is one of the most well-known spices and medicinal plants
worldwide that has been used since ancient times to treat a plethora of diseases including …

RETRACTED ARTICLE: Bio synthesis, comprehensive characterization, and multifaceted therapeutic applications of BSA-Resveratrol coated platinum nanoparticles

S Faisal, MH Tariq, Abdullah, S Zafar, Z Un Nisa… - Scientific Reports, 2024 - nature.com
This study examines the manufacturing, characterization, and biological evaluation of
platinum nanoparticles, which were synthesized by Enterobacter cloacae and coated with …

Synthesis of novel carbazole hydrazine-carbothioamide scaffold as potent antioxidant, anticancer and antimicrobial agents

İ Çapan, M Hawash, MT Qaoud, L Gülüm… - BMC chemistry, 2024 - Springer
Background Carbazole-based molecules containing thiosemicarbazide functional groups
are recognized for their diverse biological activities, particularly in enhancing therapeutic …

Explainable artificial intelligence-assisted virtual screening and bioinformatics approaches for effective bioactivity prediction of phenolic cyclooxygenase-2 (COX-2) …

M Rudrapal, KK Kirboga, M Abdalla, S Maji - Molecular Diversity, 2024 - Springer
Abstract Cyclooxygenase-2 (COX-2) inhibitors are nonsteroidal anti-inflammatory drugs that
treat inflammation, pain and fever. This study determined the interaction mechanisms of …

Flavonoids and flavonoid-based nanoparticles for osteoarthritis and rheumatoid arthritis management

H Wahnou, Y Limami, M Oudghiri - BioChem, 2024 - mdpi.com
Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands
advanced therapeutic approaches. In this context, flavonoids, a diverse group of naturally …

Astaxanthin targets IL-6 and alleviates the LPS-induced adverse inflammatory response of macrophages

Y Wu, MA Bashir, C Shao, H Wang, J Zhu, Q Huang - Food & Function, 2024 - pubs.rsc.org
Numerous natural compounds are recognized for their anti-inflammatory properties
attributed to antioxidant effects and the modulation of key inflammatory factors. Among them …

Receptor-based pharmacophore modeling, molecular docking, synthesis and biological evaluation of novel VEGFR-2, FGFR-1, and BRAF multi-kinase inhibitors

HT Abdel-Mohsen, MA Ibrahim, AM Nageeb… - BMC chemistry, 2024 - Springer
A receptor-based pharmacophore model describing the binding features required for the
multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, and BRAF) were …

Anti-Parkinson potential of hesperetin nanoparticles: in vivo and in silico investigations

PK Pasala, P Dsnbk, M Rudrapal… - Natural Product …, 2024 - Taylor & Francis
Parkinson's disease (PD) is characterised by the gradual demise of dopaminergic neurons.
In recent years, there has been significant interest in herbal treatments. In this study …

Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer

A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …