Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

[HTML][HTML] Assessing the performance of ChatGPT in answering questions regarding cirrhosis and hepatocellular carcinoma

YH Yeo, JS Samaan, WH Ng, PS Ting… - Clinical and …, 2023 - ncbi.nlm.nih.gov
Methods ChatGPT's responses to 164 questions were independently graded by two
transplant hepatologists and resolved by a third reviewer. The performance of ChatGPT was …

Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Emerging Burden

S Batool, K Morton Cuthrell, N Tzenios… - … Research Journal of …, 2022 - publish7promo.com
Liver is the largest solid organ in the body that performs over 100 functions. It removes the
toxins and waste products from the blood stream, maintains healthy blood sugar levels …

Management of hepatocellular carcinoma: a review

ZJ Brown, DI Tsilimigras, SM Ruff, A Mohseni… - JAMA …, 2023 - jamanetwork.com
Importance Hepatocellular carcinoma (HCC) is the sixth most common malignancy and
fourth leading cause of cancer-related death worldwide. Recent advances in systemic and …

Global epidemiology and genetics of hepatocellular carcinoma

MR Toh, EYT Wong, SH Wong, AWT Ng, LH Loo… - Gastroenterology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide. Classically, HCC
develops in genetically susceptible individuals who are exposed to risk factors, especially in …

Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

DQ Huang, HB El-Serag, R Loomba - Nature reviews Gastroenterology …, 2021 - nature.com
One quarter of the global population is estimated to have nonalcoholic fatty liver disease
(NAFLD). The incidence of nonalcoholic steatohepatitis (NASH) is projected to increase by …

Changing epidemiology of hepatocellular carcinoma in Asia

C Zhang, Y Cheng, S Zhang, J Fan, Q Gao - Liver International, 2022 - Wiley Online Library
Liver cancer is the fifth most common cancer and the second leading cause of malignant
death in Asia, and Asia reports 72.5% of the world's cases in 2020. As the most common …

Targeted therapy for hepatocellular carcinoma

A Huang, XR Yang, WY Chung, AR Dennison… - Signal transduction and …, 2020 - nature.com
The last 3 years have seen the emergence of promising targeted therapies for the treatment
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …

[HTML][HTML] Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in hepatocellular carcinoma

A Sharma, JJW Seow, CA Dutertre, R Pai, C Blériot… - Cell, 2020 - cell.com
We employed scRNA sequencing to extensively characterize the cellular landscape of
human liver from development to disease. Analysis of∼ 212,000 cells representing human …