[HTML][HTML] Metabolite interactions between host and microbiota during health and disease: Which feeds the other?

Y Zhang, R Chen, DD Zhang, S Qi, Y Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Immunometabolic crosstalk during bacterial infection

G Rosenberg, S Riquelme, A Prince, R Avraham - Nature microbiology, 2022 - nature.com
Following detection of bacteria, macrophages switch their metabolism from oxidative
respiration through the tricarboxylic acid cycle to high-rate aerobic glycolysis. This …

Tuberculosis: advances and challenges in development of new diagnostics and biomarkers

G Walzl, R McNerney, N du Plessis, M Bates… - The Lancet Infectious …, 2018 - thelancet.com
Tuberculosis remains the leading cause of death from an infectious disease worldwide.
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

S Ehrt, D Schnap**er, KY Rhee - Nature Reviews Microbiology, 2018 - nature.com
Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Cross-species RNA-seq for deciphering host–microbe interactions

AJ Westermann, J Vogel - Nature Reviews Genetics, 2021 - nature.com
The human body is constantly exposed to microorganisms, which entails manifold
interactions between human cells and diverse commensal or pathogenic bacteria. The …

Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism

A Serafini, L Tan, S Horswell, S Howell… - Molecular …, 2019 - Wiley Online Library
Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular
pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans …

Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis

T Laval, L Chaumont, C Demangel - Immunological Reviews, 2021 - Wiley Online Library
While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Intracellular Mycobacterium tuberculosis exploits multiple host nitrogen sources during growth in human macrophages

K Borah, M Beyß, A Theorell, H Wu, P Basu… - Cell reports, 2019 - cell.com
Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …

Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy

DPS Chang, XL Guan - Metabolites, 2021 - mdpi.com
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly
successful intracellular pathogen with the ability to withstand harsh conditions and reside …