The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease
muscle mass and strength, and undermine postural stability, culminating in an elevated risk …

Over the past decade, the number of publications using micro-computed tomography (μCT)
imaging in preclinical in vivo studies has risen exponentially. Higher spatial and temporal …

Results: Macrophage and T-cell markers were upregulated in SM of obese compared with
lean humans. SM of obese mice had higher expression of inflammatory cytokines, with …

Ipragliflozin is a novel and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor that
induces sustained increases in urinary glucose excretion by inhibiting renal glucose …

Mesenchymal stem cells (MSCs) are defined by their ability to self‐renew and differentiate
into the cells that form mesodermal tissues such as bone and fat. Low magnitude …

Background Cell behavior is the key to tissue regeneration. Given the fact that most of the
cells used in tissue engineering are anchorage-dependent, their behavior including …

In humans, aging is characterized by the progressive decline in biological, physiological,
and psychological functions, and is a major risk factor in the development of chronic …

Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent
a leading cause of adult morbidity worldwide. Currently available pharmacological therapies …

Marrow adipose tissue (MAT), associated with skeletal fragility and hematologic
insufficiency, remains poorly understood and difficult to quantify. We tested the response of …