To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

Cell motility is regulated by multiple processes, including cell protrusion, cell retraction, cell–
matrix adhesion, polarized exocytosis and polarized vesicle trafficking, each of which is …

Hippo effectors YAP/TAZ act as on–off mechanosensing switches by sensing modifications
in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has …

Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosis,
a form of scarring that increases muscular tissue rigidity and decreases cardiac contractility …

The tightly coordinated, spatiotemporal control of actin filament remodeling provides the
basis of fundamental cellular processes, such as cell migration and adhesion. Specific …

Adhesion and morphogenesis of many non-muscle cells are guided by contractile
actomyosin bundles called ventral stress fibers. While it is well established that stress fibers …

Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …

Metastasis is a significant health issue. The standard mode of care is combination of
chemotherapy and targeted therapeutics but the 5-year survival rate remains low …

Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until
dissection or rupture, requiring surgical intervention as the only available treatment. Here …

Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The …