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Immune response in COVID-19: what is next?
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …
A long way to go: caspase inhibitors in clinical use
Caspases are an evolutionary conserved family of cysteine-dependent proteases that are
involved in many vital cellular processes including apoptosis, proliferation, differentiation …
involved in many vital cellular processes including apoptosis, proliferation, differentiation …
T cell apoptosis characterizes severe Covid-19 disease
Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1–infected patients
Chronic HIV-1 infection is generally characterized by progressive CD4+ T cell depletion due
to direct and bystander death that is closely associated with persistent HIV-1 replication and …
to direct and bystander death that is closely associated with persistent HIV-1 replication and …
Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response
Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2
condition (PASC) that persists for months after infection. Here we evaluate the immune …
condition (PASC) that persists for months after infection. Here we evaluate the immune …
Role of cytokines in experimental and human visceral leishmaniasis
Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …
are no effective prophylactic measures and therapeutics available against VL. Recently, new …
Combination anti–PD-1 and antiretroviral therapy provides therapeutic benefit against SIV
GH Mylvaganam, LS Chea, GK Tharp, S Hicks… - JCI …, 2018 - pmc.ncbi.nlm.nih.gov
Therapeutic strategies that augment antiviral immunity and reduce the viral reservoir are
critical to achieving durable remission of HIV. The coinhibitory receptor programmed death-1 …
critical to achieving durable remission of HIV. The coinhibitory receptor programmed death-1 …
The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection
CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
JC Milligan, TU Zeisner, G Papageorgiou… - Biochemical …, 2021 - portlandpress.com
The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented …
syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented …
Caspase family in autoimmune diseases
W Zhang, H Wu, Y Liao, C Zhu, Z Zou - Autoimmunity Reviews, 2024 - Elsevier
Programmed cell death (PCD) plays a crucial role in maintaining tissue homeostasis, with its
primary forms including apoptosis, pyroptosis, and necroptosis. The caspase family is …
primary forms including apoptosis, pyroptosis, and necroptosis. The caspase family is …