The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders
CS Leite, GA Bonafé, J Carvalho Santos… - International journal of …, 2022 - mdpi.com
Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer
(CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data …
(CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data …
The NF-κB pathway and cancer stem cells
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …
Apoptotic signaling pathways in glioblastoma and therapeutic implications
Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is
due to increased invasion, migration, proliferation, angiogenesis, and a decreased …
due to increased invasion, migration, proliferation, angiogenesis, and a decreased …
NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age
GK Gray, BC McFarland, SE Nozell… - Expert review of …, 2014 - Taylor & Francis
Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM)
5 years ago, tremendous strides have been made in the understanding of these two …
5 years ago, tremendous strides have been made in the understanding of these two …
The role of NF-κB inhibitors in cell response to radiation
S Molavi Pordanjani… - Current medicinal …, 2016 - ingentaconnect.com
It is well documented that ionizing radiation (IR) activates the transcription factor (NF-κB)
which is a trigger for resistance cancer cells to treatment. It is involved in activation of pro …
which is a trigger for resistance cancer cells to treatment. It is involved in activation of pro …
Implications of Rho GTPase signaling in glioma cell invasion and tumor progression
SP Fortin Ensign, IT Mathews, MH Symons… - Frontiers in …, 2013 - frontiersin.org
Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a
highly locally invasive cell population, as well as abundant proliferative cells …
highly locally invasive cell population, as well as abundant proliferative cells …
Natural small molecules targeting NF-κB signaling in glioblastoma
Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate
various cellular activities, including propagation, differentiation, motility, and survival …
various cellular activities, including propagation, differentiation, motility, and survival …
PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma
Z Zhang, Z Wang, K Huang, Y Liu, C Wei, J Zhou… - Cancer Letters, 2019 - Elsevier
Despite the clinical success of temozolomide (TMZ), its sensitivity remains a major challenge
in glioblastoma (GBM). Here, we show that PLK4 affects TMZ sensitivity by regulating the …
in glioblastoma (GBM). Here, we show that PLK4 affects TMZ sensitivity by regulating the …
Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and-resistant …
TA Barone, CA Burkhart, A Safina, G Haderski… - Neuro …, 2017 - academic.oup.com
Background The survival rate for patients with glioblastoma (GBM) remains dismal. New
therapies targeting molecular pathways dysregulated in GBM are needed. One such clinical …
therapies targeting molecular pathways dysregulated in GBM are needed. One such clinical …
Unlocking the NF-κB conundrum: embracing complexity to achieve specificity
Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating
regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB …
regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB …