Approximation and inference methods for stochastic biochemical kinetics—a tutorial review

D Schnoerr, G Sanguinetti… - Journal of Physics A …, 2017 - iopscience.iop.org
Stochastic fluctuations of molecule numbers are ubiquitous in biological systems. Important
examples include gene expression and enzymatic processes in living cells. Such systems …

Data-driven statistical learning of temporal logic properties

E Bartocci, L Bortolussi, G Sanguinetti - … on formal modeling and analysis of …, 2014 - Springer
We present a novel approach to learn logical formulae characterising the emergent
behaviour of a dynamical system from system observations. At a high level, the approach …

Precise parameter synthesis for stochastic biochemical systems

M Češka, F Dannenberg, N Paoletti, M Kwiatkowska… - Acta Informatica, 2017 - Springer
We consider the problem of synthesising rate parameters for stochastic biochemical
networks so that a given time-bounded CSL property is guaranteed to hold, or, in the case of …

[HTML][HTML] Smoothed model checking for uncertain continuous-time Markov chains

L Bortolussi, D Milios, G Sanguinetti - Information and Computation, 2016 - Elsevier
We consider the problem of computing the satisfaction probability of a formula for stochastic
models with parametric uncertainty. We show that this satisfaction probability is a smooth …

[HTML][HTML] System design of stochastic models using robustness of temporal properties

E Bartocci, L Bortolussi, L Nenzi… - Theoretical Computer …, 2015 - Elsevier
Stochastic models such as Continuous-Time Markov Chains (CTMC) and Stochastic Hybrid
Automata (SHA) are powerful formalisms to model and to reason about the dynamics of …

On the robustness of temporal properties for stochastic models

E Bartocci, L Bortolussi, L Nenzi… - arxiv preprint arxiv …, 2013 - arxiv.org
Stochastic models such as Continuous-Time Markov Chains (CTMC) and Stochastic Hybrid
Automata (SHA) are powerful formalisms to model and to reason about the dynamics of …

Temporal logic based monitoring of assisted ventilation in intensive care patients

S Bufo, E Bartocci, G Sanguinetti, M Borelli… - … Applications of Formal …, 2014 - Springer
We introduce a novel approach to automatically detect ineffective breathing efforts in
patients in intensive care subject to assisted ventilation. The method is based on …

Data-driven and model-based verification via Bayesian identification and reachability analysis

S Haesaert, PMJ Van den Hof, A Abate - Automatica, 2017 - Elsevier
This work develops a measurement-driven and model-based formal verification approach,
applicable to dynamical systems with partly unknown dynamics. We provide a new …

U-check: Model checking and parameter synthesis under uncertainty

L Bortolussi, D Milios, G Sanguinetti - International Conference on …, 2015 - Springer
Novel applications of formal modelling such as systems biology have highlighted the need
to extend formal analysis techniques to domains with pervasive parametric uncertainty …

LTL model checking based on binary classification of machine learning

W Zhu, H Wu, M Deng - IEEE access, 2019 - ieeexplore.ieee.org
Linear Temporal Logic (LTL) Model Checking (MC) has been applied to many fields.
However, the state explosion problem and the exponentially computational complexity …